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  • Podquisition 214: Little Shop Of Horrors Without The Plant

    How do you do Little Shop of Horrors without the plant? One self-aggrandizing drama teacher tried it. Also, we wrap up 2018's games and look forward to 2019's games. As you do.

  • The Spin-off Doctors: Treasure Of The Four Crowns

    What can even be said about this hot nonsense? Treasure of the Four Crowns is a very special B movie in which dinosaur attacks barely warrant a mention and everything has to explode. It's a real... head turner.

  • a16z Podcast: The Science and Business of Innovative Medicines

    with Vas Narasimhan (@vasnarasimhan), Jorge Conde (@jorgecondebio), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) On average, only 1 out of 20 medicines works when we actually bring them into the human body, and these rates of success haven't moved much in the pharma industry overall in the past 15 years, despite much scientific progress. Because if you really think about it, it's incredible that we find any human medicine that works at all, given that human beings are the product of billions of years of evolution, and represent an incredibly complex system we do not fully understand. Yet the business of the pharma industry -- and Novartis in particular, which covers everything from generics to innovative medicines -- is not that different from other large enterprises when it comes to managing R&D and pipelines of ideas, talent, and sales. So in this conversation, a16z bio general partners Jorge Conde and Vijay Pande with Sonal Chokshi interview Vas Narasimhan, CEO of Novartis. How does the world's largest producer of medicines in terms of volume -- 70. billion. doses. a. year. -- balance the science and the business of innovation? How does an enterprise at such vast scale make decisions about what to build vs. buy, especially given the fast pace of science today? How does it balance attitudes between "not invented here" and "not invented yet"? Narasimhan also takes us through the latest trends in therapeutics, such as cell and gene therapies (like CAR-T for cancer and more); RNA-based modalities; and others -- a sweeping tour from small molecules to large molecules to proteins and other modalities for making medicines. But where does tech come into all this, and where are we, really, on science becoming engineering? Why do both big companies and bio startups now need to get market value signals (not just approvals!) from payers earlier in the process of making therapeutics? And beyond all that, how could clinical trials be reinvented? Finally, what should all scientific (and all technical) leaders know when it comes to leadership? All this and more in this episode of the a16z Podcast, recorded recently on the road while at the J.P.M. health conference in San Francisco.

  • a16z Podcast: What’s Next for Marketplace Startups (Hint: Services)

    The past and future of marketplace startups -- where are we? Ever since eBay popularized an internet meeting place for buyers and sellers of, well, just about everything, we’ve been waiting for 100 other at-scale marketplaces for everything else, including services. So in this hallway-style episode of the a16z Podcast (originally recorded as a video) Li Jin -- co-author with Andrew Chen of this post -- chats with a16z Deal & Research team operating partner about why there aren’t 100 thriving marketplaces for services yet... And what’s changing to make this next wave of marketplace startups super exciting.

  • a16z Podcast: All About Synthetic Biology

    with James J. Collins, Vijay Pande (@vijaypande), and Hanne Tidnam (@omnivorousread) The idea of 'designing biology' -- once science fiction -- has over the last 20 years become just... science. In this episode, a16z bio general partner Vijay Pande with Hanne Tidnam talk all about the field of synthetic biology with James J. Collins, professor of bioengineering at MIT. Collins, whose work in synthetic biology and systems biology pioneered the field, has also launched a number of companies and received numerous awards and honors (including a MacArthur "Genius" Award, an NIH Director's Pioneer Award, and Sanofi-Institut Pasteur Award). This wide-ranging conversation about the birth of synthetic biology covers everything from the founding story of the discipline to what "engineering and designing" biology really looks like in action -- when instead of engineering electrons, you are engineering toggle switches for genes -- to the disciplinary differences (and synergies) between how biologists and engineers see the world. What are the engineering and design principles, techniques, approaches that work best when applied to science? How does building a company in this new space look different, in terms of platforms and products? And how is this new field changing education in science, all the way down to kits that allow you to play with the machinery of a cell... at home... and even in middle school?

  • Episode 80 - Bungie & Activision Split Destiny?
    Gaming Illuminaughty

    No Clips Danny O Dwyer joins the join crew in episode 80 to talk Bungie, favorite games of 2018, OverWatch drama, The Epic Store and more!

  • 105 – Top 10 da CES 2019

    Mais um ano, mais uma CES! E como já é de costume, preparamos a nossa lista com as 10 novidades mais interessantes que vimos no evento. Aperta o play e vem com a gente! Participantes: - @mobilon - @paulohiga - @viviwerneck - @barbaaa

  • Runde #197: Lob, Tadel und Unverständnis
    Auf ein Bier GamesPodcast

    Sebastian wollte loben, tadeln und Unverständnis äußern, als wären wir englische Gouvernanten. Andre und Jochen waren sich sicher, dass sie zumindest zwei dieser Anforderungen erfüllen können. Und so ging’s los in eine wilde Folge über geliebte und gehasste Spielerfahrungen. Timecodes: 00:00 - Einführung 09:38 - Zeitlich begrenzte Demos 27:30 - Beeindruckende Demos 36:42 - Todesanimationen und Gore 53:56 - Lore in Rollenspielen und schlecht erklärte Spielsysteme 01:17:37 - Crafting und Inventory- Management 01:36:39 - Singleplayer- DLCs und ein drohender Plattformenkrieg auf dem PC

  • Agent Janice SPEAKS - The WAN Show Jan 11 2019

    Savage Jerky: Use offer code LTT to save 10% on Savage Jerky at Freshbooks: For your unrestricted 30 days free trial, go to and enter in “The WAN Show” in the how you heard about us section. Private Internet Access: Sign up for Private Internet Access VPN at Forum Link: Apply to work at Floatplane Media: Floatplane Account Migration Details: Podcast Link: TBD Timestamps (Courtesy of Nightcore Prototype Zero) 0:00 starts to the JAN show 2:20 intro 3:02 ground rulez 3:26 Janice’s story 5:51 funny joke ( please laugh ) 8:16 Linus stops talking 9:06 best experience on pre-sale side 9:58 worst experience 12:37 tech support 16:36 new merch 18:00 what would Janice buy 25:33 floatplane questions 34:00 super chats 39:29 last question 42:27 last last question 47:00 Janice grabs Dennis and leaves (and her money) 47:45 SPONSORS WOO! (Denis runs in front of camera) 48:31 fresh books 49:18 PIA 49:38 SAVAGE jerky 51:54 CES talk 1:01:28 Denis on OLED 1:08:13 Linus shows new Hisense demo 1:12:16 end of JAN Show ( superchats ) 1:14:55 merch store and Luke is hiring 1:16:31 requirements 1:17:12 migration for floatplane 1:20:52 real end and Dennis waving underwear 1:21:01 outro

  • نشرة الأخبار… الثلاثاء 15 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • نشرة الأخبار… الاثنين 14 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • 14.01 Digitund: kuidas uus ID-kaart kontaktivabalt tööle hakkaks?
    Geenius Raadio

    Eestis on juba üle 10 000 inimese, kel on uus ID-kaart. Miks see kaart mõnes kohas ei tööta, kuidas see võiks kontaktivabalt tööle hakata ja kas me võiks Eesti ID-kaardiga ka suurtesse välismaistesse platvormidesse sisse logida? Saate teemad: - Eesti kõige populaarsemad telefonid 2018 - miks Huawei töötaja Poolas pokri pisteti? - Apple'i laadimismatt ikkagi vist tuleb - mida asjalikku CESi messil näidati - uue ID-kaardid hädad ja võimalused Saatejuhid Hans Lõugas ja Henrik Roonemaa, külas Margus Arm riigi infosüsteemi ametist.

  • Has Wrestling Gone Too Far? - Dude Soup Podcast #208
  • نشرة الأخبار… الأحد 13 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • The Best of CES

    WIRED’s Gadget Lab team kicks off the new year with a wrap-up of the year’s biggest electronics show. Plus, an interview with Reddit’s Jen Wong.

  • نشرة الأخبار… السبت 12 يناير 2019

    نشرة الأخبار تأتيكم يوميًا من البوابة العربية للأخبار التقنية في تمام الساعة: 4 صباحًا بتوقيت جمهورية مصر العربية. 5 صباحًا بتوقيت المملكة العربية السعودية. 6 صباحًا بتوقيت الإمارات العربية المتحدة.

  • 631: Kicking off 2019!
    Larry Hryb (Major Nelson)

    Larry Hryb, Xbox Major Nelson Jeff Rubenstein, Xbox Live's Rubes We discuss the holidays, and look at the latest news for the New Year

  • 12.01 Restart: Kaspar Korjus räägib, kuidas päriselt e-residentsust tehti
    Geenius Raadio

    Restardis on sel nädalal külas Kaspar Korjus, kes äsja teatas ametist lahkumisest. Üldiselt me proovime igast saatest leida mõne hoogsama mõtte, mida pealkirjaks vormistada, siis selle saate puhul andsime lihtsalt alla, sest neid oli liiga palju. Ühesõnaga, tänasest saatest saab teada, kuidas Kaspar Korjus ja kolleegid päriselt e-residentsust tegid, mida pidi tegema selleks, et seadused tekiks ja erinevad ametkonnad koostööd hakkaks tegema ning mida mõtles Korjus siis, kui ta Tokyos hotellis istus ja end maailma ühe suurema telekanali eetrist e-residentsust tutvustamas avastas. Saatejuhi Henrik Roonemaa uudisteportaalist ja Taavi Kotka.

  • E893 All #AskJason! Working in VC, non-revenue projects, cliches, networking, negotiating co-founder
  • CES 2019 Wrap up, featuring Michael Fisher of TheMrMobile/Mobile Nations
    Android Authority

    Wrapping up a long week of technology and innovation can be hard to do in one podcast, so Adam and Jonathan are joined by Michael Fisher, a.k.a. @TheMrMobile. We broadcasted from the Blue Podcast Studio suite at Treasure Island with some sweet Blue gear and we discussed the week of tech that was. Recorded January 10, 2019 5:00 PM PST Topics covered: Android Authority’s CES Top Picks 2019 Awards: Our favorite products from the show The Printbrush Fluidity Remote (as described in Dronerush’s Best Drones of CES Awards) Nubia X looks stunning with smartly-integrated secondary display Alcatel’s 1C and 1X hands-on: Budget as budget gets Hisense U30 quietly lands at CES: Yet another 48MP phone with punch-hole camera Dell Alienware Area-51m (as described in our Best Laptops of CES 2019 video) Google Assistant Connect makes it easier for companies to create smart products The DJI Osmo Pocket is a great drone camera Why Royole is the company to watch in 2019 The robots of CES 2019 Special Guest appearance by: Michael Fisher - @themrmobile The Android Authority podcast is: Adam Doud - @DeadTechnology Jonathan Feist - @JFeist1 / @DroneRush Joe Hindy - @ThatJoeHindy Produced by Adam Doud